Lecture, three hours; discussion, one hour; laboratory, one hour. First course in biostatistical methods intended for graduate students in biostatistics to prepare students pursuing careers as practicing biostatisticians. Prior knowledge of probability or statistics not assumed. Students should have working knowledge of calculus and be very comfortable with mathematical and algebraic reasoning. Introduction to basic concepts in analysis, presentation of data, and statistical aspects of design of studies. Special emphasis is given to application of statistical methods to public health, medical, biological, and health sciences. Interpretation and communication of statistical findings is stressed. Focus on methodology, applications, and concepts rather than mathematical statistics or probability theory. S/U or letter grading.