(Same as Bioinformatics M221, Computer Science CM221, and Human Genetics M260A.) Lecture, four hours; discussion, two hours. Requisites: Computer Science 32 or Program in Computing 10C with grade of C- or better, and one course from Civil and Environmental Engineering 110, Electrical and Computer Engineering 131A, Mathematics 170A, Mathematics 170E, or Statistics 100A. Prior knowledge of biology not required. Designed for engineering students as well as students from biological sciences and medical school. Introduction to bioinformatics and methodologies, with emphasis on concepts and inventing new computational and statistical techniques to analyze biological data. Focus on sequence analysis and alignment algorithms. Concurrently scheduled with course CM160A. S/U or letter grading.