Lecture, four hours; laboratory, three hours (five weeks only). Requisite or corequisite: Physics 1C or 5B or 6C. Introduction to modern microscopy technologies used in biochemistry, medicine, microbiology, and nano research. Basic image formation principles of microscopy, methods for sample preparation, imaging, data acquisitions, and three-dimensional reconstruction and visualization. Fluoresce, confocal, and super-resolution light microscopy; transmission electron microscopy, electron tomography, and three-dimensional cryo-electron microscopy; and atomic force and other scanning probe microscopy modalities. Practical experience in research provided through five carefully designed electron microscopy laboratory modules. P/NP or letter grading.