Lecture, four hours; discussion, one hour; outside study, seven hours. Addresses fundamentals, materials, processes, manufacturing, and devices fabrication for nanogenerators. Showcases key biomedical applications, in particular, nanogenerators made for circulatory system, neural system, cell modulation, microbe disinfection, and biodegradable electronics. Functionality of nanogenerators can serve for energy, sensing, and therapy purposes in bioengineering. Nanogenerators can be key components to realize autonomous intelligent closed-loop sensing and therapeutic system on human body for personalized health care to conquer medical fields in Internet of Things era. Letter grading.