(Same as Bioengineering CM145.) Lecture, four hours; discussion, one hour; outside study, seven hours. Requisite: course 45 or Life Sciences 7C. Selected topics in molecular biology that form foundation of biotechnology and biomedical industry today. Topics include recombinant DNA technology, molecular research tools, manipulation of gene expression, directed mutagenesis and protein engineering, DNA-based diagnostics and DNA microarrays, antibody and protein-based diagnostics, genomics and bioinformatics, isolation of human genes, gene therapy, and tissue engineering. Concurrently scheduled with course CM245. Letter grading.