Lecture, two hours; laboratory, eight hours. Requisites: Life Sciences 3, 4, and 23L, or 7A, 7B, 7C, 23L, and 107. Course 104AL is requisite to 104BL. Limited to Molecular, Cell, and Developmental Biology and Microbiology, Immunology, and Molecular Genetics majors. Discovery-based research using sea urchins as model system. Students determine expression of unstudied sea urchin genes using combination of molecular biology and computation techniques. May not be repeated for credit. Letter grading.