Lecture, three hours; discussion, one hour. Requisites: Life Sciences 7A, 7B, 7C, 23L, 107. Contribution of cellular metabolism to biology of human diseases including cancer and diabetes. Exploration of major alterations of cellular metabolism in disease; tools and technologies that enable detailed characterization of metabolic alterations; therapeutic targeting of metabolic vulnerabilities; and utility of altered cellular metabolism as diagnostic and predictive biomarkers. Letter grading.