(Same as Biostatistics M257.) Lecture, three hours; discussion, one hour. Requisites: Biostatistics 250A or Statistics 100C, Mathematics 115A. Preparation for quantitative research in statistics and data sciences. Numerical analysis and hands-on computing techniques for handling big data. Numerical analysis topics include computer arithmetic, solving linear equations, Cholesky factorization, QR factorization, regression computations, eigenvalue problems, iterative solvers, numerical optimization, and design and analysis of statistical simulation experiments. Computing techniques include basics of R programming, reproducible research using R and RStudio, collaborative research, parallel computing, and cloud computing. No prior knowledge of R assumed. S/U or letter grading.