Lecture, three hours. Requisites: courses 111A, 111B. Students gain understanding of how cancer-causing mutations co-opt normal physiological processes to promote disease progression. Covers homeostatic challenges induced by cancer and cancer therapies. Heavy focus on how animal models are designed and used to study human cancer. Topics include genetic engineering and preclinical analysis of transgenic mouse models of lung cancer, melanoma, and breast cancer. Classes are mixture of lecture and discussion focused on relevant classical and current literature. Letter grading.