Lecture, four hours; outside study, eight hours. Requisites: course CM145, Mathematics 31A, 31B, 32A, 33B. Systems approach to intracellular network identification and analysis. Transcriptional regulatory networks, protein networks, and metabolic networks. Data from genome sequencing, large-scale expression analysis, and other high-throughput techniques provide bases for systems identification and analysis. Discussion of gene-metabolic network synthesis. Concurrently scheduled with course C246. Letter grading.