Lecture, four hours; outside study, eight hours. Requisite: course 171A or equivalent. Preparation: familiarity with differential equations (course 107 or Electrical and Computer Engineering 102). Covers mathematical modeling of biological and ecological systems using deterministic approaches. Derivation of kinetic models for control of gene expression, gene networks, cellular signaling, and viral infections. Nonlinear and linearized analysis of feedback mechanisms leading to oscillations and bistability. Modularity and robustness in interconnected networks in presence of parameter uncertainty and disturbances. Feedback engineering for setpoint regulation of cellular processes and bioproduction. Letter grading.