Lecture, two hours. Requisites: course 100 or 200A, and Biostatistics 100A, or Public Health 200A and 200B. Offers theoretical and practical understanding of systematic reviews and meta-analysis of clinical trials and observational studies. Students learn how to conduct systematic literature search, assess quality of selected studies, identify sources of heterogeneity, conduct meta-analysis, and understand standards of reporting on meta-analyses. Offers practical training in meta-analyses and meta-regression using STATA software. Letter grading.