Lecture, four hours; outside study, eight hours. Requisites: course CM245, Life Sciences 1, 2, 3, 4, 23L, Mathematics 31A, 31B, 32A, 33B. Systems approach to intracellular network identification and analysis. Transcriptional regulatory networks, protein networks, and metabolic networks. Data from genome sequencing, large-scale expression analysis, and other high-throughput techniques provide bases for systems identification and analysis. Discussion of gene-metabolic network synthesis. Letter grading.