(Same as Bioinformatics M222 and Chemistry CM260B.) Lecture, four hours; discussion, two hours. Requisites: course 32 or Program in Computing 10C with grade of C- or better, and one course from Civil Engineering 110, Electrical and Computer Engineering 131A, Mathematics 170A, Mathematics 170E, or Statistics 100A. Course CM221 is not requisite to CM222. Designed for engineering students as well as students from biological sciences and medical school. Development and application of computational approaches to biological questions, with focus on formulating interdisciplinary problems as computational problems and then solving these problems using algorithmic techniques. Computational techniques include those from statistics and computer science. Concurrently scheduled with course CM122. Letter grading.