(Same as Bioengineering M273.) Lecture, four hours; discussion, one hour; outside study, seven hours. Covers state-of-art and emerging biosensors in context of molecular diagnostics. Students learn relevant biology and biochemistry pertinent to molecular diagnostics. Students gain thorough understanding of interfaces between bioparticles, biofluids, and electronics. Topics include biosensor performance parameters, modes of detection, sample preparation challenges, microfluidics, and emerging wearable biosensing platforms, as well as proteomics, genomics, and DNA sequencing technologies. Letter grading.