(Same as Chemistry CM260B and Computer Science CM222.) Lecture, four hours; discussion, two hours. Requisites: Computer Science 32 or Program in Computing 10C with grade of C- or better, and one course from Civil Engineering 110, Electrical and Computer Engineering 131A, Mathematics 170A, Mathematics 170E, or Statistics 100A. Course M221 is not requisite to M222. Designed for engineering students as well as students from biological sciences and medical school. Development and application of computational approaches to biological questions, with focus on formulating interdisciplinary problems as computational problems and then solving these problems using algorithmic techniques. Computational techniques include those from statistics and computer science. Letter grading.