Lecture, four hours. Enforced requisite: course 215A or 215B. Design and implementation of studies of dynamic interventions, including improvement initiatives and pragmatic clinical trials. Provides skills in research methods for improvement and implementation studies in clinical settings (including community-based settings) and health systems. Completion of improvement research projects that demonstrate student competence in design and implementation. Fundamentals in research design and methods for conducting rigorous inferential evaluation in real world of implementation science, with emphasis on methods for generalizing results of improvement and implementation studies involving dynamic testing. Emphasis on case studies and applications so students gain skills in design and implementation. Letter grading.