Lecture, two hours; discussion, one hour. Requisites: courses 202, 206A, 210A, 210B, Biostatistics 100B. Introduction to wide array of quantitative research study designs. In-depth examination of dynamic interaction between research question and process and theoretical approaches to experimental- and many quasi-experimental- and non-experimental-study designs. Examination of potential threats to validity of and other design characteristics that are associated with research-study designs. Letter grading.