Lecture, three hours; discussion, one hour. Requisites: Life Sciences 2, 3, 4, and 23L, or 7A, 7B, 7C, and 23L. Quantitative description of molecular systems that underlie myriad phenotypes in living cells. Topics include various -omics fields and high-throughput technologies, network biology, and synthetic biology. Introductory lectures on molecular biology, emerging bioinformatic approaches, and systems modeling integrated with discussions of their applications in disease-related research. Review of recent literature to gain overall perspectives about new science of systems biology. Letter grading.