(Same as Biostatistics M236.) Lecture, three hours; laboratory, one hour. Requisite: Biostatistics 200B or another substantial regression course. Analysis of continuous responses for which multivariate normal model may be assumed. Students learn how to think about longitudinal data, plot data, and how to specify mean and variance of longitudinal response. Advanced topics include introductions to clustered, multivariate, and discrete longitudinal data. S/U or letter grading.