Lecture, four hours; outside study, eight hours. Overview of informatics-based applications of medical imaging with focus on various advances in field, such as content-based image retrieval, computer-aided detection/diagnosis, and imaging genomics. Introduction to core concepts in information retrieval (IR), reviewing seminal papers on evaluating IR systems and their use in medicine (e.g., teaching files, case-based retrieval, etc.). Examination of specific techniques for image feature extraction and processing, feature representation, indexing and querying, and classification (machine/deep learning). Survey of clinical applications of these techniques and ongoing challenges. Letter grading.