(Same as Physiological Science CM227.) Lecture, three hours; discussion, one hour. Enforced requisite: Physiological Science 111B. Understanding of reproductive neuroendocrinology throughout mammalian lifespan, with emphasis as appropriate on human condition. Discussion of general concepts of endocrine feedback and feed-forward loops, sexual differentiation, and structure and function for components of hypothalamo-pituitary gonadal axis. Exploration of sex differences in physiology and disease. Letter grading.