Lecture, four hours. Introduction of active research topics in bioinformatics. Topics vary by instructor research area and include statistical genomics, epigenomics, single-cell analysis, metagenomics, and diagnostic informatics. Overview of research area and associated biological and technological background. Discussion of representative problems and presentation of their computational modeling and solutions. Students gain overview of current topics in bioinformatics and learn how to model and solve biological problems with computational methods. Letter grading.