Lecture, three hours; laboratory, four hours. Requisites: Life Sciences 7A, 7B, 7C, and 107, and Life Sciences 30A and 30B or Mathematics 3A, 3B, and 3C or Mathematics 31A and 31B, and Life Sciences 40 or Statistics 10 or 13. Quantitative analysis of genetic circuits that control behavior of biological systems, including prokaryotic model organisms and multicellular developmental systems. Introduction of basic principles of systems biology through specific examples. Application of these principles in designing synthetic genetic circuits. Letter grading.