Lecture, three hours; discussion, one hour. Requisites: courses 200A, 200B, 200C, 250A. Theoretical foundation for linear models with applications to different types of problems in biomedical field. Emphasis on mathematical training and understanding of theory of linear models, including linear mixed models and topics that may include theory and tests for various types of model misspecification, such as heteroscedasticity and outliers. Other selected topics may include ridge regression, Bayesian estimation in linear models, REML, prediction, and model selection issues. Some data analysis, instructions for STATA provided. Letter grading.