Lecture, three hours; discussion, one hour. Requisites: Chemistry 153A, and Life Sciences 2, 3, and 4 or 7A, 7B, and 7C. Designed for junior/senior Biochemistry and life sciences majors. Use of disease mechanisms as pedagogical tools to develop higher-order knowledge of basic scientific concepts. Integration of concepts from genetics, molecular and cell biology, physiology, and biochemistry to create molecular solutions to problem of inherited neuromuscular disease. Letter grading.