(Same as Computational and Systems Biology M187 and Computer Science CM187.) Lecture, four hours; outside study, eight hours. Requisites: course M182 or CM186 or Computational and Systems Biology M150; and research experience (course 199, Computational and Systems Biology 199, Computer Science 199, or equivalent). Closely directed, interactive, and real research experience in active quantitative systems biology research laboratory. Direction on how to focus on topics of current interest in scientific community, appropriate to student interests and capabilities. Critiques of oral presentations and written progress reports explain how to proceed with search for research results. Major emphasis on effective research reporting, both oral and written. Concurrently scheduled with course CM287. Letter grading.