Lecture, two hours; laboratory, two hours. Enforced Requisite: Life Sciences 40 or Statistics 10 or 13. Overview of and application of advanced statistical methods that go beyond linear models and mean comparison, including bootstrapping, permutations, Bayesian statistics, mixed models, clustering, and network analysis. At course end students should be able to explain which statistical approaches are appropriate for different types of research questions and critically evaluate their outputs. All statistical analysis conducted in R. Concurrently scheduled with course C172. S/U or letter grading.