Lecture, three hours; discussion, two hours. Requisite: course 165A. Continuation of course 165A. Molecular biology of eukaryotic cell nucleus, with focus on structure, organization, replication, and repair of eukaryotic genome; eukaryotic gene expression, including transcription, translation, and transport; cell cycle and cancer. Study of advanced specialized topics to allow integrated approach to molecular cell biology. Material presented in context of experimental questions and answers to incorporate concept of scientific method and recent advances in cell biology research. Exposure in discussions to current literature that directly relates to information examined in lectures. Letter grading.