Lecture, four hours; discussion, one hour; outside study, seven hours. Requisite: course 45. Introduction to design and synthesis of biomaterials for regenerative medicine, in vitro cell culture, and drug delivery. Biological principles of cellular microenvironment and design of extracellular matrix analogs using biological and engineering principles. Biomaterials for growth factor, and DNA and siRNA delivery as therapeutics and to facilitate tissue regeneration. Use of stem cells in tissue engineering. Concurrently scheduled with course C224. Letter grading.