Lecture, two and one half hours; discussion, 30 minutes. Requisites: courses 110 and 115, or Neuroscience M101A, M101B, and M101C. Limited to juniors/seniors. Presentation of biological and behavioral approaches to anxiety and depression, taken from laboratory and applied research. In addition to overview of major principles from each approach, emphasis on areas in which significant research advances have recently occurred. Examination of concordance and discordance between results from laboratory and applied research. P/NP or letter grading.